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Rxn-45 bioprocessing probe
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Measuring principle
Raman spectroscopy
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Spectral coverage
Probe spectral coverage is limited by the coverage of the analyzer being used.
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Maximum laser power into probehead (mW)
< 499
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Sample interface
Temperature:
-30 to 150 °C / -22 to 302 °F
Temperature ramp:
≤ 30 °C/min
≤ 54 °F/min -
Pressure
Max pressure:
13.8 barg / 200 psig -
Wetted materials
Body: 316L stainless steel
Window: Proprietary material, optimized for bioprocesses
Process connection: PG13.5 for industry standard sensor housings, welded port connectors available
Surface finish: Ra 15 with electropolish
Adhesive: USP Class VI and ISO993 compatible -
Fiber optic cable
Cable sold separately
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Length
120 mm / 4.73 inch
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Diameter
12 mm / 0.48 inch
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Sterilization method
CIP/SIP
Field of application
The Raman Rxn-45 probe capitalizes on the power of Raman in bioprocess manufacturing by measuring multiple, specific components in real-time for continuous, around-the-clock process feedback. It also meets the daunting sampling requirements of compliance, sterilization, port compatibility, and convenience. The Raman Rxn-45 probe was designed for installation in development and cGMP stainless-steel reactors and is successfully used to provide an analytical “eye” into large-scale bioprocesses.
Cell culture: glucose, lactate, amino acids, cell density, titer, and moreFermentation: glucose, glycerol, acetate, methanol, ethanol, biomass, and more
Benefits
Measures multiple components in real-time for automated 24/7 process feedbackProvides long-term measurement stabilityOffers a suitable surface finish for cGMP manufacturingProvides compatibility with industry standard bioreactor side ports and sensor housingsOffers the flexibility of being installed in development and production reactorsReduces sterilization and cleaning burdens with CIP/SIP standard compatibility